In working with my consulting clients, I often discover that many are unaware of the benefits of using Apple Time Machine for backup.
Automatic versioned backup saves your butt.
Photographers might be keen on reading my discussion of backing up the Adobe Lightroom catalog file with Time Machine.
Time Machine is a great solution that solves multiple problems very conveniently, but it is not a substitute for regular backups, to be stored away from the machine.
I wouldn’t work without Time Machine, it has saved me on numerous occasions, even if it’s something as basic as restoring yesterday’s Mail preferences so that Apple Mail would stop malfunctioning.